Michael J. Fox Foundation for Parkinson’s Research Request for Applications for Edmond J. Safra Core Programs for PD Research

Michael J. Fox Foundation for Parkinson’s Research Request for Applications for Edmond J. Safra Core Programs for PD Research

Program Goal
With the current Request for Applications (RFA), The Michael J. Fox Foundation for Parkinson’s Research
(MJFF) seeks investigators to join the effort to develop new treatments and ultimately a cure for Parkinson’s
disease (PD). The Edmond J. Safra Core Programs for PD Research, part of our annual Pipeline Programs, is a
series of three funding opportunities that seek investigator-initiated proposals focused on the following critical
points along the translational pathway to new PD therapies:

· Testing Novel Hypotheses: Funding from our Rapid Response Innovation Awards program quickly
supports high-risk, high-reward projects with little to no existing preliminary data, but potential to
significantly impact our understanding or treatment of PD.
· Validating Novel Targets: Funding from our Target Validation program supports work demonstrating
whether modulation of a novel biological target has impact in a PD-relevant animal model – an essential
early step to the development of potential targeted therapies.
· Clinical Testing of Novel Therapies: Funding from our Clinical Intervention Awards program supports
clinical testing of promising PD therapies that may significantly and fundamentally improve treatment for
people with PD.

The Pipeline Programs, including The Edmond J. Safra Core Programs for PD Research, reflect our portfolio
approach to supporting work across multiple stages of development. Applicants are encouraged to carefully
consider the specific goals of each funding program to match the state of development for their project. Each
program requires submission of a custom ‘pre-proposal’ form summarizing the novel hypothesis, new target or
clinical trial being proposed. Applicants should not submit the same idea into multiple programs; rather, choose
the stage that is right for you. MJFF staff may choose at its discretion to move a proposal into the program that it
feels is most appropriate to the apparent stage of work.

Companies interested in support for early hypothesis testing, target validation or clinical efforts are welcome to
apply to the above programs. However, companies seeking support for preclinical therapeutic development
should also consider the separately launched, industry-only Therapeutics Development Initiative. Please see the
MJFF website for more information (www.michaeljfox.org).

Pre-proposals Due

Spring: December 15, 2009 6:00pm US ET
Fall: June 1, 2010 6:00pm US ET

For additional information about this initiative, contact the Foundation at research@michaeljfox.org.

If you would like to contact the Foundation, please send an email, call toll-free at 1-800-708-7644, or contact us by regular mail at the following address:

The Michael J. Fox Foundation for Parkinson's Research
Church Street Station
P.O. Box 780
New York, NY 10008-0780