2009 Request for Barth Syndrome Research Proposals

2009 Request for Barth Syndrome Research Proposals

The Barth Syndrome Foundation, Inc. (BSF) and its affiliates are pleased to announce the availability of funding for research internationally on the natural history, biochemical basis, and treatment of Barth syndrome.

Background

Barth syndrome is a serious X-linked genetic condition associated with cardiomyopathy, neutropenia, skeletal muscle weakness, exercise intolerance, growth delay, and diverse biochemical abnormalities (including defects in mitochondrial metabolism and phospholipid biosynthesis). Because many clinical and biochemical abnormalities of Barth syndrome remain poorly understood, we are seeking proposals for research that may shed light on any aspect of the syndrome. We are determined to find improved treatments—and ultimately a cure—for this rare and under-diagnosed disorder.

Types of Proposals Sought

We are most interested in providing “seed money” to be used by experienced investigators for the testing of initial hypotheses and collection of preliminary data leading to successful long-term funding by the National Institutes of Health (NIH) and other major granting institutions around the world. In addition, we are especially interested in attracting new investigators to the very interesting field of Barth syndrome research.

Funding

We anticipate awarding several one– or two–year grants of up to $40,000 each. Funds will be available as soon as the successful grant applicants have been notified.

Process

We have a simple grant process. Applications should be of 10–15 pages in length and must follow the instructions listed on the BSF website. In general terms, detailed information about the specific aims, significance, research design and methods, personnel, and budget will be required, along with evidence of application to the relevant Institutional Review Board for any work involving human subjects.

Completed proposals will be forwarded to the BSF Scientific and Medical Advisory Board (as well as outside reviewers, in certain cases) for evaluation. Based on the recommendations of the Scientific and Medical Advisory Board, the BSF Board of Directors and those of our three international affiliates will make the final funding decisions for the grant applications. Please review our “Grants Awarded” webpage for a listing of grants that BSF has awarded to date.

Deadline

The deadline for submission of completed research grant applications from interested researchers is October 31, 2009. Grants will be awarded early March 2010.

Contact Information

Matthew J. Toth, PhD
Science Director
Barth Syndrome Foundation, Inc.
mtoth@barthsyndrome.org