9 funding opportunities found in this category. Change the order of results: Newest First Oldest First Expiring Soonest Expiring Latest Lowest Award to Highest Highest Award to Lowest
Request for Proposals: Parkin Biology and Therapeutic Development Studies
The Michael J. Fox Foundation for Parkinson’s Research (MJFF) seeks to fund pre-clinical studies that investigate the biological function and therapeutic potential of Parkin protein. The ultimate goal is to identify therapeutic agents that alter the course of Parkinson’s disease.
There will be two separate ‘Tracks’ that may be pursued for support around Parkin as follows:
TRACK A – Biology
TRACK B – Therapeutic Development
Applicants may submit proposals to both Track A and Track B but it will need to do so by submitting separate applications that provide independent experimental designs for each. Applicants will be asked to justify the approach and to provide details of their study design.
Biological Studies
How will the proposed studies impact our understanding of Parkin:
As an enzyme
In cell biology
Therapeutic Development Studies
Current drug development stage with clear justification
Provide research operation plan, including feasibility, timelines, and all assays to be performed
Provide a clear description of the properties of the lead compound(s)/biologic
Please ensure that you utilize the correct template upon submission.
DEADLINES
Informational Conference Call*: June 6, 2013, 12:00 p.m. EST
Pre-proposals Due: June 19, 2013, 6:00 p.m. EST
Full Application Invites Sent to Applicants: July 3, 2013
Full Applications Due (by invite only): August 14, 2013
Anticipated Award Announcement: October, 2013
Anticipated Funding: November, 2013
*MJFF will hold a 45-minute conference call at the time listed above to clarify and explain the goals of this funding initiative and answer applicant questions. To participate in the call and receive call-in details, please RSVP via email to conferencecalls@michaeljfox.org, reporting “Parkin 2013” in the subject of the email.
BACKGROUND AND RATIONALE
PD is a progressive neurodegenerative disease affecting nearly five million people worldwide, with significant prevalence growth expected due to an aging population. Current therapies are effective in addressing only the mild-to-moderate motor symptoms of the disease and have significant long-term side effects. There are few specific drugs available that target the numerous non-motor aspects of the disease or the underlying degenerative process.
Though most cases of PD are considered idiopathic, investigators are increasingly identifying genes linked to this disease. However, these monogenic variants account for only a small proportion of all PD cases. Research on genetically implicated targets and associated pathways has the potential to yield critical insight and the development of therapeutics that may impact sporadic PD patients as well.
Parkin (PARK2) was identified as a gene linked to autosomal recessive juvenile forms of PD. Since its original discovery, many mutations and deletions have been identified (1). Parkin gene encodes a multidomain protein that contains E3 ubiquitin ligase activity that plays a role in the regulation of numerous cellular activities including proteasomal degradation of substrates but also ubiquitin-mediated signaling (1). Parkin has also been suggested to function as a transcription factor, regulating p53 expression (2) independent of its ligase activity.
Thus there is the distinct possibility that promoting Parkin activation may have implications in ameliorating cellular signaling pathways as well as regulation of degradation pathways. Given recent advances in understanding Parkin structure, investigators now have at hand a tangible means of optimizing small-molecule development through structure-based drug design.
PURPOSE
The goal of the Parkin Biology & Therapeutic Development Program is to support:
1. Studies that provide critical insight into the biological mechanisms of Parkin function
2. Discovery and development of therapeutic agents that have the potential to modulate Parkin function in a manner that will alter the course of Parkinson’s disease progression.
Although most traditional therapeutics targeting modulation of enzymatic activity involve small-molecule development, MJFF is also open to alternative strategies, including gene therapy and biological (non-pharmaceutical) approaches that can have significant impact on Parkin activity. Moreover, as drug targets may be shared among multiple diseases and/or drugs may hit multiple disease targets, MJFF is also interested in drug repositioning of molecules for Parkin that have been approved or shown to be clinically safe for other indications.
Proposals may seek support of key steps along the entire therapeutic pipeline, including:
High-throughput screening
Primary assay development and validation
IC50 generation/validation in second primary assay and chemistry support for hit ranking and clustering
Hit-to Lead and Lead Optimization
Chemistry support
In vitro and in vivo PK, PK/PD relationships, toxicity studies
Applicants are asked to develop a clear plan, including major ‘go/no go’ decision milestones, for moving a therapeutic strategy toward ultimate clinical utility in people with PD. Investigators new to PD research are encouraged to collaborate with experienced PD scientists and/or companies to ensure the greatest chance for success.
REFERENCES
1.Cell Mol Life Sci (2012) 69:3053-3067
2.Neurodegenerative Dis 2012 10:49-51
FUNDS AVAILABLE
MJFF will commit up to $2 million to the Parkin Biology & Therapeutic Development Program with the intention to support multiple awards. The requested support should be commensurate with the stage of development and work proposed.
Investigators applying to Track A (Biology) may request up to $125,000 in support (inclusive of indirect costs) for up to one year.
For those applying to Track B (Therapeutic Development) there is no set budget limit for proposals and applicants may request up to two years of funding for preclinical development.
No more than 25% (Academic institutions) or 10% (for-profit institutions) of direct costs may go to indirect costs. Please see the program instructions, Administrative Guidelines and our FAQ on MJFF indirect cost policy for details. MJFF reserves the right to reduce the duration and budget based on its review and final funding decision.
Eligibility Requirements
Applications may be submitted by:
U.S. and non-U.S. biotechnology/pharmaceutical companies or other for-profit entities, either publicly or privately held,
U.S. and non-U.S. entities, public and private non-profit entities, such as universities, colleges, hospitals, laboratories, units of state and local governments, and eligible agencies of the federal government.
As therapeutic programs may require many kinds of expertise, MJFF encourages industry and academic collaborations when appropriate. Given the significant coordination and leadership necessary for this program, post-doctoral fellows are NOT eligible to apply as PIs.
American College of Cardiology Foundation Young Investigator Awards Competition
The Young Investigator Awards competition encourages and recognizes young scientific investigators of promise, upon whom progress in the field of cardiology is dependent. A manuscript and abstract summarizing any problem that relates to cardiovascular disease whether it be in etiology, pathophysiology, diagnosis, or therapy.
Award Categories include the following:
1. ACCF/Herman K. Gold Young Investigator Awards in Molecular and Cellular Cardiology
2. Physiology, Pharmacology and Pathology
3. Clinical Investigations, Congenital Heart Disease and Cardiac Surgery
4.Cardiovascular Health Outcomes and Population Genetics
*Doctorate level nurses, physician assistants and clinical pharmacists in research are strongly encouraged to apply in this category
Eligibility: Physicians, scientists, medical students, and other healthcare providers currently in residency or fellowship programs, or are no more than three years out of training. PhD, PharmD or DNP candidates who are no more than three years out of training may also apply.
Note: Candidates will be eligible for this award up to four years after completion of training if more than three months of family or sick leave was taken during training or in the first three years after completion of training.
The Award: The first place winner for each category receives $2,000, second place winners receive $1,000; three honorable mentions in each category receive $500. Travel, hotel and meals up to $1,500 will be reimbursed for all 20 finalists to attend the YIA Competition at ACC.14 in Washington, DC.
Funding Source: Support for the ACCF/Herman K. Gold Young Investigator Awards in Molecular and Cellular Cardiology is provided by a grant from CV Path Institute and the family of Herman K. Gold.
Deadline: October 11, 2013
For more information: Email Kristin Robertson or call 800-253-4636, ext. 6390.
American Hearing Research Foundation Regular Grants
The American Hearing Research Foundation funds an average of five research grants each year that investigate various aspects of hearing and balance disorders related to the inner ear. Grants are for $20,000 for one year of research. Priority is given to investigators early in their careers who need seed funds to generate results and data that can be used to support later application for larger grants (i.e., NIH grants) in the future.
AHRF Regular Grants
AHRF grant proposals are due on August 1 of the year before funding begins in January. Proposals are reviewed by the AHRF Research Committee in mid-October and applicants are notified as to the status of their grants immediately. The AHRF uses a five point scale for scoring grants, with one being the highest score and 5 the lowest.
Grant proposals should relate to the hearing or balance functions of the ear. Both basic and clinical studies may be proposed that investigates aspects of the auditory and vestibular systems including but not limited to genetics, neurotology, anatomy, auditory processing, molecular and cellular biology, therapeutic studies, and investigations of current or experimental devices (i.e. cochlear implants).
Applicants should hold the MD, PhD or equivalent degree(s) and be associated with a university or hospital in the United States.
Grant recipients need to submit progress reports by April 1. Reports may be included on our website and/or newsletter. Recipients also must notify the AHRF in advance of any publication of their research funded by the AHRF. Recipients should also notify the AHRF if any aspect of their funded research is reported in the media. It is our goal to highlight research results and publications.
Recipients are also required to submit a final report of their research by the end of January after the completion of their funded year of research.
Grant funds may only be used for direct costs, including salaries of technical and supporting staff, equipment related to the research, and supplies. Funding may not be sued for salary of the principle investigator, travel or conference attendance, or educational costs. No-cost extensions of research past the funded year is granted based on approval of the Research Committee.
American Hearing Research Foundation 8 S. Michigan Ave. Ste. 1205 Chicago, IL 60603 Phone: (312) 726-9670 Fax: (312) 726-9695
1st Annual 2013 Conference on International Translational Nanomedicine Student Awards
July 26 – 28, 2013 Boston, Massachusetts
Abstracts will be accepted until June 1st, 2013.
The abstract submission system for the 1st Annual 2013 Conference on International Translational Nanomedicine (ITNano) at Northeastern University, Boston, MA is now open. The conference will be in July 26 – 28, 2013.
Papers can be submitted in the following categories of nanomedicine research:
Bioimaging & Drug Delivery
Biosensing & Biophotonics
Biophysics
Modeling
Instrumentation
Regenerative Medicine
Rehabilitative Engineering
Tissue Engineering
Biomaterials
Biomechanics & Mechanobiology
Biofuels & Bioenergy
Molecular Cell Engineering
Synthetic Biology
Quantitative Systems Biology
Stem Cells
Bioengineering Education
Education
Start-up Companies
Any research area of interest at the intersection of nanotechnology and medicine.
The conference will be held on the campus of Northeastern University in Boston, MA, USA. The conference will include plenary speakers, oral and poster presentations, and numerous activities specifically for undergraduate and graduate students. As the focus of the conference is to highlight translational nanomedicine research, we will also focus on highlighting start-up companies and well-established companies in the nanomedicine sectors.
The conference organizer is Prof. Tom Webster, Chair, Department of Chemical Engineering, Northeastern University
Student Grants
A limited number of student registration and travel grants will be awarded by June 1st.
To apply for a registration and travel grant, students should apply by ensuring their abstract was submitted by the abstract deadline (June 1st) and should submit: 1) a letter of recommendation from the advisor indicating the importance of the student to attend the conference. Student grants should be submitted to Chair and Prof. Tom Webster.
Student Poster Awards
Prizes will be award for the best undergraduate, graduate, and post-doctoral student posters. In each case, the lead author must be a graduate student and must be present to win.
Call for Nominations: Nemko Prize in Cellular or Molecular Neuroscience
Nominations for the 2013 award are due Wednesday, June 5.
The Nemko Prize in Cellular or Molecular Neuroscience, supported by The Nemko Family, recognizes a young neuroscientist's outstanding PhD thesis advancing understanding of molecular, genetic, or cellular mechanisms underlying brain function, including higher function and cognition.
Recipients receive a $2,500 prize and complimentary registration, transportation (economy air or ground), and two nights hotel accommodations for the SfN annual meeting. The SfN president presents the prize at a lecture at the meeting.
Eligibility
Nominees must have a thesis submitted and approved between January 1 and December 31 of the preceding calendar year.
Submit all materials using SfN's award nomination site. Include the following:
One nomination letter from the nominee's PhD mentor(s). No additional letters will be accepted.
4–6-page (typed, double-spaced) thesis abstract with names and departmental affiliations of thesis committee members
Current CV (include date of thesis defense)
If you have questions, email awards@sfn.org or call 202-962-4000.
Call for Applications: New Research Grants for Novel Approaches to Lupus
Grant Application Deadline: May 30, 2013
The Lupus Research Institute (LRI) invites applications for financial support for idea-driven, novel research projects relevant to basic, translational or clinical investigation in lupus. The Novel Research Grant program will run in parallel with the LRI’s global Distinguished Innovator Award program.
Research applications will be judged principally on novelty of the hypotheses, scientific quality, strength of approach, relevance to lupus, and likelihood of success. Creativity will be valued. Rationale for the hypotheses proposed rather than amount of preliminary data will be emphasized.
Continuations of long-term research projects are not appropriate for this submission.
Projects on aspects of the disease that have been less extensively studied and applications from investigators in diverse disciplines, including those who may not have previously worked in lupus, are encouraged.
While the Institute encourages projects based on novel explorations of human lupus biology—innovative studies that use human material to address the physiological, cellular, molecular and/or genetic basis of human lupus—projects solely based on cellular, molecular, and/or animal models are also encouraged.
Both established and new investigators may apply. Applicants should hold advanced degrees and be affiliated with institutions of higher learning in the United States. Grant application research plans are limited to six pages. Annual funding of up to $100,000 per year, beginning December 2013, for a term of up to three years, will be awarded for approved projects.
For additional information please contact Laura Hack, Grants Administrator lhack@lupusny.org or 212.685.4118.
To submit an application, please visit proposalCentral at http://proposalcentral.altum.com/.
Application must be received by May 30, 2013
FacioScapuloHumeral Muscular Dystrophy Society Research Grants and Fellowships
The FSH Society offers basic research grants, research fellowships and postdoctoral fellowships to support research relevant to understanding the molecular genetics and cause of Facioscapulohumeral Muscular Dystrophy (FSHD).
To obtain an application, please submit a letter of intent. The letter of intent should contain a single page introductory cover letter plus a one or two page descriptive summary of the proposed research – enough for a decision from the Scientific Advisory Board. A well conceived and tight rationale for a research project can easily lend itself to one page. The letter of intent may be submitted at any time to the FSH Society, attention: Dr. David Housman, Scientific Advisory Board Chairman.
Indirect costs are not included, but fringe benefits are considered part of personnel costs and are included.
Deadlines for receipt of grant, research fellowship and postdoctoral fellowship applications are February 28/29 and August 31 of each year.
Payment for each year of the award is made in two equal installments - the first on the activation date (or the anniversary thereof) and the second six months after the beginning of the award period (or the anniversary thereof). A five to ten page progress-to-date package will be sent by the grantee at the end of nine months to the SAB for review. The subsequent year(s) of funding will not be activated prior to a review of the nine-month progress report and an explanation of any changes that the work necessitates or changes in specific aims for the next year. The progress report is required at nine months after the start of each award year.
Propagatable reagents and biomaterials, including monoclonal antibodies, recombinant DNAs, cell lines, propagatable cells, and animal models created using FSH Society funds are to be made freely available to other investigators following publication of the relevant paper. The Society's position is that there be no restrictions or proprietary rights in materials produced with our support.
Grant Applications
Support will be given for research projects expected to contribute to identifying and understanding the basic defect in FSHD. Areas of interest include tissue, cell and molecular biology studies of FSHD and the development of animal models for FSHD. Proposals are sought for research that involves isolation and characterization of the causative gene(s) and understanding of the genetic, neuromuscular and developmental mechanisms of the disease. Further, there is interest in the development of gene therapy and other therapeutic programs that may arise from that understanding.
The range of awards for regular research grants is typically between $30,000 and $45,000 per year. Grants are usually for one year, with the possibility of renewal for up to two years.
In addition to its regular grants, the Society offers a special Delta Railroad Construction Grant for innovative proposals accelerating the discovery of treatments and a cure for FSHD. A Delta Grant can be funded for one year for up to $40,000.
As the Society has limited funds, our grants are considered "seed money." If the project shows promise, it is hoped that other institutions will fund it thereafter. Many FSH Society fellows and grantees have noted that these grants have enabled them to go on to receive larger grants from other institutions.
Generally, awards do not include salaries of the principal investigator. Indirect costs are not included, but fringe benefits are considered part of personnel costs and can be included.
Grant applications should be completed and sent by e-mail to the FSH Society.
A reference sheet is enclosed with each grant application for use by three or more applicant-selected personnel acquainted with the applicant’s relevant experience.
If reprints are included in the application, please provide electronic copies.
Applications are reviewed by primary reviewers as well as by the FSH Society's Scientific Advisory Board. The Society will notify the applicant about the funding decision by letter only.
Senior Researcher Fellowship and Postdoctoral Fellowship Applications
Support will be given for research projects that contribute to identifying and understanding the basic defect of FSHD.
The range of awards for fellowships is typically between $30,000 and $50,000. Fellowships are usually for one year, with the possibility of renewal for up to three years.
Indirect costs are not included, but fringe benefits are considered part of personnel costs and can be included.
Fellowships may be renewed for second and third years, subject to satisfactory progress reports at nine months.
A reference sheet is enclosed with each fellowship application for use by three or more applicant-selected personnel acquainted with the applicant’s relevant experience.
Applications should include the applicant's curriculum vitae, plus that of the research sponsor, and send by email to the FSH Society. If reprints are included in the application, please include provide electronic copies.
The Society will notify the applicant about the funding decision by letter only.
FSH Society, Inc. BBRI R353 64 Grove Street Watertown, MA 02472 USA
Telephone: (617) 658-7878, -7877 or (781) 275-7781
Office hours are Monday through Friday, 9 AM to 5 PM EST. Voicemail messages may be left after hours.
Fax: (617) 658-7879 or (781) 275-7789
E-mail: info@fshsociety.org
American Association of Anatomists Outreach Grants
Applications due: August 1 (for program or meeting funding the next calendar year)
AAA’s Outreach Grant Program provides funding for workshops, symposia, and meetings organized by AAA members, either as stand-alone activities or under the umbrella of other national or international societies. Supported activities may either be educational—such as anatomy workshops for high school students—or scientific. Targeted audiences include researchers, educators, and students at all levels. Additionally, Outreach Grants may be used to help support an event for National Lab Network events.
For the AAA/Wiley Research Meetings Outreach Grants Program and the AAA/Wiley Three-Year Research Meetings Outreach Grants Program, some preference will be given to meetings that will use the funds for student/ postdoc/ young investigator travel fellowships.
AAA Education Outreach Grant
AAA offers grants for education programs designed to enhance teaching skills or interest educators and students at all academic levels in anatomy as a discipline. Proposals are judged by the AAA Education Outreach Awards Subcommittee.
AAA/Wiley Research Meetings Outreach Grant
Funding is available to support non-AAA workshops, symposia, or meetings organized by AAA members. Preference will be given to research areas viewed as AAA strategic priorities—imaging, cellular and molecular anatomy, neurobiology, systems biology, and vertebrate development. Some preference will be given to programs that use the funds for student/ postdoc/ young investigator travel fellowships. Proposals will be judged by a subcommittee of the AAA Program Committee, with the participation of the editors of The Anatomical Record and Developmental Dynamics.
AAA/Wiley Three-Year Research Meetings Outreach Grant
AAA may select one meeting each year as deserving of ongoing support over a three-year period. AAA may choose one such meeting a year so that in a given year, up to three such meetings will be supported. Beyond fulfilling the regular criteria for Research Meetings Outreach Grants outlined here, three-year funded meetings will be encouraged to consider meeting with the AAA Annual Meeting/Experimental Biology as a guest society and encouraged to publish a special issue in one of AAA’s journals. With this in mind, AAA’s journal editors will be involved in the selection process and the meetings being considered for a three-year award will be ranked on the following criteria:
•Potential contribution to mission of an AAA journal (Anatomical Record, Anatomical Sciences Education, Developmental Dynamics)
•Potential to become a guest society at an AAA Annual Meeting
•Likelihood of future AAA involvement of attendees
The second and third year of a three-year grant will be contingent on receipt of a satisfactory progress report within 60 days following each meeting. All applications for three-year grants that are not accepted will automatically be considered within the pool of applications for a one-year Research Meetings Outreach Grant.
All three grant programs will follow the same application process and funding cycle, with proposals due August 1 for funding in the following calendar year.
Only AAA members are eligible to apply for a grant. No individual or project will be funded two years in a row for an Education Outreach Grant or regular Research Meetings Outreach Grant. Members submitting separate proposals for the same meeting will be asked to consolidate their requests.
Application Process
Any AAA member interested in receiving an Outreach Grant should submit a proposal, not to exceed two pages, stating the goals and particulars of the project and the expected audience. Sources of matching funds or contributions from other societies should be indicated, along with an itemized budget detailing expenses for speaker travel, housing, on-site fees, and ancillary supplies or equipment. Also include details on how AAA might benefit from your program and how AAA support will be acknowledged. If you have received an AAA Outreach Grant in the past, you must provide details about the success of your earlier meeting or project. AAA support generally will not exceed $3,000 a year. Travel and housing expenses of the proposer will generally not be covered by the grant. A follow-up report on the meeting will be required in the format of an article to be published in the AAA Newsletter. Recipients will be asked to provide AAA with an electronic list of participants and to distribute or display appropriate AAA and Wiley information at their event, as requested.
Deadline
The submission deadline for grant proposals is August 1 (for program or meeting funding the next calendar year).
Review Process
The primary criteria for evaluating proposals include visibility and scientific impact, quality of participants, potential value to AAA, and visibility of AAA support. Additional criteria are described above. Based on subcommittees’ recommendations and funds available, the Board will select proposals for support. Recipients will be notified by late November of the calendar year in which the application is submitted; funds are disbursed in January. Neither the subcommittees nor the Board are obligated to make awards if satisfactory proposals have not been submitted or to provide the full amount requested.
Call for Nominations: American Association of Anatomists Young Investigator Awards
Nomination deadline: August 15th
Materials deadline: September 15th
Nominations are due each year on August 15; nominees are then asked to submit three representative papers by September 15. Winning nominees and their nominators will be notified of selection in late October and will be expected to present a lecture at the AAA Annual Meeting/EB 2012.
Beginning with nominations made in 2008, AAA’s Young Investigator Awards combine three long-standing AAA awards with a new award to recognize investigators in the early stages of their careers who have made important contributions to biomedical science through their research in cell/molecular biology, developmental biology, comparative neuroanatomy, or the morphological sciences. Candidates should be within 10 years of their highest earned degree at the time of nomination. It is not necessary that nominators or nominees be AAA members.
AAA’s Young Investigator Awards Selection Committee is comprised of eight (8) members appointed by the current or incoming President to represent the various disciplines covered by these awards. Committee members will serve a two-year term with one member serving a one-year term as chair in the final year. The position of chair will rotate among the disciplines covered by these awards. The committee will review all nominations and determine which of the following prizes to award in a given year. It is not required that each award be made annually.
R.R. Bensley Award in Cell Biology
This award, first given in 1979, recognizes a cell biologist who has made a distinguished contribution to the advancement of anatomy through discovery, ingenuity, and publications in the field of cell biology. The successful candidate will be an independent cell biologist whose publications have had substantial impact on his/her field.
C.J. Herrick Award in Neuroanatomy
Established in 1962, this award recognizes investigators who have made important contributions to the field of comparative neuroanatomy and have demonstrated remarkable promise of future accomplishments. The area of comparative neuroanatomy is defined broadly; previous awardees are outstanding scientists who have made contributions to areas of neuroscience, including neurochemistry, development, neurocytology, neuroendocrinology, neurophysiology, and molecular neurobiology.
H.W. Mossman Award in Developmental Biology
This award was established in 2001 to recognize investigators in the early stages of their careers who have made important contributions to the field of developmental biology, as broadly defined, and have demonstrated remarkable promise of future accomplishments.
AAA Morphological Sciences Award
This award was established in 2008 to recognize investigators in the early stages of their careers who have made important contributions to biomedical science through research in the morphological sciences, as broadly defined, and have demonstrated remarkable promise of future accomplishments.
AAA Young Investigator Award recipients will present a lecture in the Young Investigator Award Symposium at the AAA Annual Meeting following their selection and will receive:
•A plaque
•A $1,000 honorarium
•Travel reimbursement (coach airfare plus 3 nights)
•Two years free membership in the American Association of Anatomists (and two years free membership for winning non-member nominators)
•Two years free registration (at early registration rate) at the AAA Annual Meeting/EB meeting, including the year of the award
NOMINATION MATERIALS
The person making the nomination only needs to submit:
1. Completed Award Nomination Form
2. Curriculum vitae of the nominee (NIH biosketch format preferred)
3. Detailed letter of recommendation that addresses the following:
•The significant research contribution(s) made by the nominee and why it is considered significant.
•Why the nominee's potential and current work is viewed as especially promising.
•The ability of the nominee to give a lecture that is dynamic, engaging, and readily understood by scientists across various subdisciplines.
•The date on which the nominee’s advanced professional degree was awarded.
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